The volume includes handwritten notes by Louis W. Knight, University of Maryland, School of Medicine Class of 1866. The notes are from sessions 1866-1867 and 1867-1869 with Dr. Nathan R. Smith; Summer 1967 with Dr. Nathan R. Smith, Dr. M.J. De Rossett, Dr. James H. Butler, Chatant, Dr. William G. Harrison, Dr. S.L. Frank, Dr. Edward G. Loring, Dr. Alan P. Smith, Dr. J.H. Straith, and Dr. W. Chew Van Bibber; sessions 1867-68 with Dr. Richard McSherry, Dr. Julian J. Chisolm and Dr. Frank Donaldson; and session 1869-70 with Dr. Julian J. Chisolm.

Topics include:  Inflammation, Wounds [Gunshot, Lacerated, Puncture, Poisoned], Fractures, Surgery [Operative, Military, Orthopedic], Dislocations, Hernia, Aneurism, Diseases of the Eye, Diseases of the Ear, Tumors, Animal Chemistry, Diseases of Children, Histology, Ophthalmology, Surgical Affections, Diseases of Women, Yellow Fever, Necrosis, Amputations, Gonorrhea, and Dislocations.

In the physical volume, pages have been torn out effecting digital pages 176-179 and 260-263. Digital pages 220 to 233 are tightly bound making some writing illegible.

Pasted into front pages there is a newspaper clipping about Dr. Nathan R. Smith, followed by an index of clinic topics and their page numbers.

Between digital pages 268 and 274 there are 102 blank pages not scanned.

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